PUBLICACIONES REPRESENTATIVAS

---

Cardona C, Sánchez-Mejías E, Dávila JC, Martín-Rufián M, Campos-Sandoval JA, Vitorica J, Alonso FJ, Matés JM, Segura JA, Norenberg MD, Rama Rao KV, Jayakumar AR, Gutiérrez A, Márquez J
Expression of Gls and Gls2 glutaminase isoforms in astrocytes
Glia 2015 Mar;63(3):365-82. doi: 10.1002/glia.22758. Epub 2014 Oct 9. PubMed

Jimenez S, Navarro V, Moyano J, Sanchez-Mico M, Torres M, Davila JC, Vizuete M, Gutierrez A, Vitorica J
Disruption of amyloid plaques integrity affects the soluble oligomers content from Alzheimer disease brains
PLoS One 2014 Dec 8;9(12):e114041. doi: 10.1371/journal.pone.0114041. eCollection 2014. PubMed

Trujillo-Estrada L, Dávila JC, Sánchez-Mejias E, Sánchez-Varo R, Gomez-Arboledas A, Vizuete M, Vitorica J, Gutiérrez A
Early neuronal loss and axonal/presynaptic damage is associated with accelerated amyloid-ß accumulation in AßPP/PS1 Alzheimer's disease mice subiculum
J Alzheimers Dis. 2014;42(2):521-41. doi: 10.3233/JAD-140495. PubMed

Trujillo-Estrada L, Jimenez S, De Castro V, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, Navarro V, Sanchez-Varo R, Sanchez-Mejias E, Davila JC, Vizuete M, Gutierrez A, Vitorica J
In vivo modification of Abeta plaque toxicity as a novel neuroprotective lithium-mediated therapy for Alzheimer's disease pathology
Acta Neuropathol Commun. 2013 Nov 12;1(1):73. PubMed

Torres M, Jimenez S, Sanchez-Varo R, Navarro V, Trujillo-Estrada L, Sanchez-Mejias E, Carmona I, Davila JC, Vizuete M, Gutierrez A, Vitorica J
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
Mol Neurodegener. 2012. doi: 10.1186/1750-1326-7-59 PubMed

Sanchez-Varo R, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Baglietto-Vargas D, Moreno-Gonzalez I, De Castro V, Jimenez S, Ruano D, Vizuete M, Davila JC, Garcia-Verdugo JM, Jimenez AJ, Vitorica J, Gutierrez A
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus
Acta Neuropathol. 2012. 123(1):53-70. doi: 10.1007/s00401-011-0896-x PubMed

Jimenez S, Torres M, Vizuete M, Sanchez-Varo R, Sanchez-Mejias E, Trujillo-Estrada L, Carmona-Cuenca I, Caballero C, Ruano D, Gutierrez A, Vitorica J
Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model
J Biol Chem. 2011. 286(21):18414-25. doi: 10.1074/jbc.M110.209718 PubMed

Baglietto-Vargas D, Moreno-Gonzalez I, Sanchez-Varo R, Jimenez S, Trujillo-Estrada L, Sanchez-Mejias E, Torres M, Romero-Acebal M, Ruano D, Vizuete M, Vitorica J, Gutierrez A
Calretinin interneurons are early targets of extracellular amyloid-beta pathology in PS1/AbetaPP Alzheimer mice hippocampus
J Alzheimers Dis. 2010. 21(1):119-32. doi: 10.3233/JAD-2010-100066 PubMed

Moreno-Gonzalez I, Baglietto-Vargas D, Sanchez-Varo R, Jimenez S, Trujillo-Estrada L, Sanchez-Mejias E, Del Rio JC, Torres M, Romero-Acebal M, Ruano D, Vizuete M, Vitorica J, Gutierrez A
Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice
J Alzheimers Dis. 2009. 18(4):755-76. doi: 10.3233/JAD-2009-1192 PubMed

López-Aranda MF, López-Téllez JF, Navarro-Lobato I, Masmudi-Martín M, Gutiérrez A, Khan ZU
Role of layer 6 of V2 visual cortex in object-recognition memory
Science 2009. 325(5936):87-9. doi: 10.1126/science.1170869 PubMed

Jimenez S, Baglietto-Vargas D, Caballero C, Moreno-Gonzalez I, Torres M, Sanchez-Varo R, Ruano D, Vizuete M, Gutierrez A, Vitorica J
Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic
J Neurosci. 2008. 28(45):11650-61. doi: 10.1523/JNEUROSCI.3024-08.2008 PubMed

PROYECTOS FINANCIADOS

---

Título: Oligómeros tóxicos del Abeta como agentes causantes de la disfunción del citoesqueleto y los procesos proteolíticos en la enfermedad de Alzheimer: búsqueda de nuevas dianas terapéuticas
Referencia: Proyecto FIS: PI12/01431
Duración: Desde 01/01/2013 hasta 31/12/2015
Investigador Responsable: Antonia Gutierrez Perez

Título: Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas. CIBERNED. Grupo Programa 1
Referencia: CB06/05/1116
Duración: Desde 01/10/2007 hasta 31/12/2013
Investigador Responsable: Antonia Gutierrez Perez

Título: Activación glial en el proceso neuroinflamatorio: una potencial diana terapéutica para la enfermedad de Alzheimer
Referencia: Proyecto CIBERNED: PI2010/08-02
Duración: Desde 01/08/2010 hasta 31/07/2013
Investigador Responsable: Antonia Gutierrez Perez